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endoplasmic reticulum stress canonical pathway  (Ingenuity Systems)

 
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    Structured Review

    Ingenuity Systems endoplasmic reticulum stress canonical pathway
    (A) qPCR performed in triplicate on the aRNA samples described in , using selected markers of the unfolded protein response (UPR) and <t>endoplasmic</t> reticulum associated degradation pathway, including ( i ) BiP , ( ii ) Calr , ( iii ) Derl2 , ( iv ) Derl3 , ( v ) Edem1 , ( vi ) ERdj4 , ( vii ) Erp72 , (viii ) Fgf21 , and ( ix ) Luman . Expression profiles are expressed as fold difference for homozygous Schmid (Schmid) or Tg cog (Cog) compared with wildtype (Wt), with profiles determined by the microarray analyses described in shaded dark grey, and profiles determined by qPCR shaded light grey. Error bars indicate standard deviation around the mean. (B) In situ analyses performed on 7 day old Wt and Schmid tibial growth plate cryosections using digoxigenin-labelled riboprobes specific for ( i , ii ) Col10a1 as well as novel markers of the UPR including ( iii , iv ) Armet , ( v , vi ) Creld2 , ( vii , viii ) Fgf21 , ( ix , x ) Luman , ( xi , xii ) Steap1 , ( xiii , xiv ) Syvn1 , and ( xv , xvi ) Wfs1 . Dashed lines demarcate approximate growth plate zone boundaries: R – Resting Zone, P – Proliferative Zone, H – Hypertrophic Zone. Boxes inset show magnified representative areas of the hypertrophic zones, to highlight the extent of riboprobe hybridization in these zones. Scale bars = 500 µm.
    Endoplasmic Reticulum Stress Canonical Pathway, supplied by Ingenuity Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/endoplasmic+reticulum+stress+canonical+pathway/pmc03174197-61-13-23?v=Ingenuity+Systems
    Average 90 stars, based on 1 article reviews
    endoplasmic reticulum stress canonical pathway - by Bioz Stars, 2026-08
    90/100 stars

    Images

    1) Product Images from "Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy"

    Article Title: Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

    Journal: PLoS ONE

    doi: 10.1371/journal.pone.0024600

    (A) qPCR performed in triplicate on the aRNA samples described in , using selected markers of the unfolded protein response (UPR) and endoplasmic reticulum associated degradation pathway, including ( i ) BiP , ( ii ) Calr , ( iii ) Derl2 , ( iv ) Derl3 , ( v ) Edem1 , ( vi ) ERdj4 , ( vii ) Erp72 , (viii ) Fgf21 , and ( ix ) Luman . Expression profiles are expressed as fold difference for homozygous Schmid (Schmid) or Tg cog (Cog) compared with wildtype (Wt), with profiles determined by the microarray analyses described in shaded dark grey, and profiles determined by qPCR shaded light grey. Error bars indicate standard deviation around the mean. (B) In situ analyses performed on 7 day old Wt and Schmid tibial growth plate cryosections using digoxigenin-labelled riboprobes specific for ( i , ii ) Col10a1 as well as novel markers of the UPR including ( iii , iv ) Armet , ( v , vi ) Creld2 , ( vii , viii ) Fgf21 , ( ix , x ) Luman , ( xi , xii ) Steap1 , ( xiii , xiv ) Syvn1 , and ( xv , xvi ) Wfs1 . Dashed lines demarcate approximate growth plate zone boundaries: R – Resting Zone, P – Proliferative Zone, H – Hypertrophic Zone. Boxes inset show magnified representative areas of the hypertrophic zones, to highlight the extent of riboprobe hybridization in these zones. Scale bars = 500 µm.
    Figure Legend Snippet: (A) qPCR performed in triplicate on the aRNA samples described in , using selected markers of the unfolded protein response (UPR) and endoplasmic reticulum associated degradation pathway, including ( i ) BiP , ( ii ) Calr , ( iii ) Derl2 , ( iv ) Derl3 , ( v ) Edem1 , ( vi ) ERdj4 , ( vii ) Erp72 , (viii ) Fgf21 , and ( ix ) Luman . Expression profiles are expressed as fold difference for homozygous Schmid (Schmid) or Tg cog (Cog) compared with wildtype (Wt), with profiles determined by the microarray analyses described in shaded dark grey, and profiles determined by qPCR shaded light grey. Error bars indicate standard deviation around the mean. (B) In situ analyses performed on 7 day old Wt and Schmid tibial growth plate cryosections using digoxigenin-labelled riboprobes specific for ( i , ii ) Col10a1 as well as novel markers of the UPR including ( iii , iv ) Armet , ( v , vi ) Creld2 , ( vii , viii ) Fgf21 , ( ix , x ) Luman , ( xi , xii ) Steap1 , ( xiii , xiv ) Syvn1 , and ( xv , xvi ) Wfs1 . Dashed lines demarcate approximate growth plate zone boundaries: R – Resting Zone, P – Proliferative Zone, H – Hypertrophic Zone. Boxes inset show magnified representative areas of the hypertrophic zones, to highlight the extent of riboprobe hybridization in these zones. Scale bars = 500 µm.

    Techniques Used: Expressing, Microarray, Standard Deviation, In Situ, Hybridization

    Transmission electron micrographs of representative chondrocytes from the (A–D) proliferative, (E–H) upper hypertrophic, (I–L) mid-hypertrophic, and (M–P) lower hypertrophic zones of 7 day old wildtype (Wt) and homozygous Schmid (Schmid) tibial growth plates. Italicized letters indicate intracellular features as follows: ER – endoplasmic reticulum, Gl – glycogen, Go – Golgi complex, N – nucleus, P – proteoglycan, V – vesicles. Scale bars = 1 µm.
    Figure Legend Snippet: Transmission electron micrographs of representative chondrocytes from the (A–D) proliferative, (E–H) upper hypertrophic, (I–L) mid-hypertrophic, and (M–P) lower hypertrophic zones of 7 day old wildtype (Wt) and homozygous Schmid (Schmid) tibial growth plates. Italicized letters indicate intracellular features as follows: ER – endoplasmic reticulum, Gl – glycogen, Go – Golgi complex, N – nucleus, P – proteoglycan, V – vesicles. Scale bars = 1 µm.

    Techniques Used: Transmission Assay



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    endoplasmic reticulum stress canonical pathway  (Ingenuity Systems)
    90
    Ingenuity Systems endoplasmic reticulum stress canonical pathway
    (A) qPCR performed in triplicate on the aRNA samples described in , using selected markers of the unfolded protein response (UPR) and <t>endoplasmic</t> reticulum associated degradation pathway, including ( i ) BiP , ( ii ) Calr , ( iii ) Derl2 , ( iv ) Derl3 , ( v ) Edem1 , ( vi ) ERdj4 , ( vii ) Erp72 , (viii ) Fgf21 , and ( ix ) Luman . Expression profiles are expressed as fold difference for homozygous Schmid (Schmid) or Tg cog (Cog) compared with wildtype (Wt), with profiles determined by the microarray analyses described in shaded dark grey, and profiles determined by qPCR shaded light grey. Error bars indicate standard deviation around the mean. (B) In situ analyses performed on 7 day old Wt and Schmid tibial growth plate cryosections using digoxigenin-labelled riboprobes specific for ( i , ii ) Col10a1 as well as novel markers of the UPR including ( iii , iv ) Armet , ( v , vi ) Creld2 , ( vii , viii ) Fgf21 , ( ix , x ) Luman , ( xi , xii ) Steap1 , ( xiii , xiv ) Syvn1 , and ( xv , xvi ) Wfs1 . Dashed lines demarcate approximate growth plate zone boundaries: R – Resting Zone, P – Proliferative Zone, H – Hypertrophic Zone. Boxes inset show magnified representative areas of the hypertrophic zones, to highlight the extent of riboprobe hybridization in these zones. Scale bars = 500 µm.
    Endoplasmic Reticulum Stress Canonical Pathway, supplied by Ingenuity Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/endoplasmic+reticulum+stress+canonical+pathway/pmc03174197-61-13-23?v=Ingenuity+Systems
    Average 90 stars, based on 1 article reviews
    endoplasmic reticulum stress canonical pathway - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) qPCR performed in triplicate on the aRNA samples described in , using selected markers of the unfolded protein response (UPR) and endoplasmic reticulum associated degradation pathway, including ( i ) BiP , ( ii ) Calr , ( iii ) Derl2 , ( iv ) Derl3 , ( v ) Edem1 , ( vi ) ERdj4 , ( vii ) Erp72 , (viii ) Fgf21 , and ( ix ) Luman . Expression profiles are expressed as fold difference for homozygous Schmid (Schmid) or Tg cog (Cog) compared with wildtype (Wt), with profiles determined by the microarray analyses described in shaded dark grey, and profiles determined by qPCR shaded light grey. Error bars indicate standard deviation around the mean. (B) In situ analyses performed on 7 day old Wt and Schmid tibial growth plate cryosections using digoxigenin-labelled riboprobes specific for ( i , ii ) Col10a1 as well as novel markers of the UPR including ( iii , iv ) Armet , ( v , vi ) Creld2 , ( vii , viii ) Fgf21 , ( ix , x ) Luman , ( xi , xii ) Steap1 , ( xiii , xiv ) Syvn1 , and ( xv , xvi ) Wfs1 . Dashed lines demarcate approximate growth plate zone boundaries: R – Resting Zone, P – Proliferative Zone, H – Hypertrophic Zone. Boxes inset show magnified representative areas of the hypertrophic zones, to highlight the extent of riboprobe hybridization in these zones. Scale bars = 500 µm.

    Journal: PLoS ONE

    Article Title: Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

    doi: 10.1371/journal.pone.0024600

    Figure Lengend Snippet: (A) qPCR performed in triplicate on the aRNA samples described in , using selected markers of the unfolded protein response (UPR) and endoplasmic reticulum associated degradation pathway, including ( i ) BiP , ( ii ) Calr , ( iii ) Derl2 , ( iv ) Derl3 , ( v ) Edem1 , ( vi ) ERdj4 , ( vii ) Erp72 , (viii ) Fgf21 , and ( ix ) Luman . Expression profiles are expressed as fold difference for homozygous Schmid (Schmid) or Tg cog (Cog) compared with wildtype (Wt), with profiles determined by the microarray analyses described in shaded dark grey, and profiles determined by qPCR shaded light grey. Error bars indicate standard deviation around the mean. (B) In situ analyses performed on 7 day old Wt and Schmid tibial growth plate cryosections using digoxigenin-labelled riboprobes specific for ( i , ii ) Col10a1 as well as novel markers of the UPR including ( iii , iv ) Armet , ( v , vi ) Creld2 , ( vii , viii ) Fgf21 , ( ix , x ) Luman , ( xi , xii ) Steap1 , ( xiii , xiv ) Syvn1 , and ( xv , xvi ) Wfs1 . Dashed lines demarcate approximate growth plate zone boundaries: R – Resting Zone, P – Proliferative Zone, H – Hypertrophic Zone. Boxes inset show magnified representative areas of the hypertrophic zones, to highlight the extent of riboprobe hybridization in these zones. Scale bars = 500 µm.

    Article Snippet: Microarray analyses were also depicted by uploading the differential expression data into the Endoplasmic Reticulum Stress Canonical Pathway from the Ingenuity Pathways Analysis (Ingenuity Systems®, www.ingenuity.com ) library of canonical pathways, further revealing similarity between the UPRs of the Schmid ( ) and Cog mice ( ).

    Techniques: Expressing, Microarray, Standard Deviation, In Situ, Hybridization

    Transmission electron micrographs of representative chondrocytes from the (A–D) proliferative, (E–H) upper hypertrophic, (I–L) mid-hypertrophic, and (M–P) lower hypertrophic zones of 7 day old wildtype (Wt) and homozygous Schmid (Schmid) tibial growth plates. Italicized letters indicate intracellular features as follows: ER – endoplasmic reticulum, Gl – glycogen, Go – Golgi complex, N – nucleus, P – proteoglycan, V – vesicles. Scale bars = 1 µm.

    Journal: PLoS ONE

    Article Title: Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

    doi: 10.1371/journal.pone.0024600

    Figure Lengend Snippet: Transmission electron micrographs of representative chondrocytes from the (A–D) proliferative, (E–H) upper hypertrophic, (I–L) mid-hypertrophic, and (M–P) lower hypertrophic zones of 7 day old wildtype (Wt) and homozygous Schmid (Schmid) tibial growth plates. Italicized letters indicate intracellular features as follows: ER – endoplasmic reticulum, Gl – glycogen, Go – Golgi complex, N – nucleus, P – proteoglycan, V – vesicles. Scale bars = 1 µm.

    Article Snippet: Microarray analyses were also depicted by uploading the differential expression data into the Endoplasmic Reticulum Stress Canonical Pathway from the Ingenuity Pathways Analysis (Ingenuity Systems®, www.ingenuity.com ) library of canonical pathways, further revealing similarity between the UPRs of the Schmid ( ) and Cog mice ( ).

    Techniques: Transmission Assay